{"id":10007730,"date":"2016-06-10T14:35:18","date_gmt":"2016-06-10T12:35:18","guid":{"rendered":"https:\/\/www.fh-joanneum.at\/?post_type=laboratories&#038;p=7730"},"modified":"2018-01-17T18:07:23","modified_gmt":"2018-01-17T16:07:23","slug":"laboratory-for-chromatographic-spectrometric-analysis","status":"publish","type":"laboratory","link":"https:\/\/www.fh-joanneum.at\/en\/labor\/laboratory-for-chromatographic-spectrometric-analysis\/","title":{"rendered":"Laboratory for Chromatographic &amp; Spectrometric Analysis"},"content":{"rendered":"<div class=\"wp-block-sidebar-layout-container margin-bottom-normal\">\n    <div\n        class=\"container-lg\"\n        style=\"--bs-gutter-x: 0;\"\n    >\n        <div\n            class=\"row\"\n            style=\"--bs-gutter-x: 0;\"\n        >\n            \n<div class=\"col-12 col-md-3 order-1 order-md-0 sidebar\">\n            \n<div\n    id=\"\"\n    class=\"wp-block-institute-card margin-bottom-normal\"\n>\n    <div class=\"container-lg\">\n                                    <div class=\"row justify-content-around\">\n                    <div class=\"col-8 col-sm-6 col-md-12\">\n                        <a\n        class=\"gesundheitsstudien institute-card\"\n        href=\"https:\/\/www.fh-joanneum.at\/en\/institute\/biomedical-science\/\"\n        target=\"_self\"\n    >\n                            <div class=\"major-bg-color\">\n            <div class=\"wrapper\">\n                <div class=\"header\">\n                    <span>Institute<\/span>\n                <\/div>\n                <h4>Biomedical Science<\/h4>\n            <\/div>\n        <\/div>\n            <span><\/span>\n                    <\/a>\n                    <\/div>\n                <\/div>\n                        <\/div>\n<\/div>\n\n<div id=\"\" class=\"wp-block-fact-box margin-bottom-normal\">\n  <div class=\"container-lg\">\n        <div class=\"row justify-content-around\">\n            <div class=\"col-8 col-sm-6 col-md-12\">\n                <div class=\"card border border-light p-3\">\n                    <ul class=\"list-unstyled mb-0\">\n                                              <li\n                          class=\"\"\n                        >\n                          <div class=\"label mb-1\">\n                            Project start \/ Laboratory launch \n                          <\/div>\n                          <div class=\"value fw-bold\">June 2009<\/div>\n                        <\/li>\n                                          <\/ul>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div\n    id=\"\"\n    class=\"wp-block-text-card card margin-bottom-normal\"\n>\n    <div class=\"container-lg\">\n        <div class=\"row justify-content-around\">\n            <div class=\"col-8 col-sm-6 col-md-12\">\n                <div class=\"border border-light p-3\">\n                    <div class=\"module-migration-sidebar-ueberschrift-text\">\n<h4 class=\"field-migration-ueberschrift\">Project coordination<\/h4>\n<p class=\"field-migration-text\">\n<ul>\n<li>Mag. Dr. Miriam Ehrnh\u00f6fer-Re\u00dfler<\/li>\n<li>Mag. Dr. Bernhard Wagner<\/li>\n<\/ul>\n<\/div>\n\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"\" class=\"wp-block-fact-box margin-bottom-normal\">\n  <div class=\"container-lg\">\n        <div class=\"row justify-content-around\">\n            <div class=\"col-8 col-sm-6 col-md-12\">\n                <div class=\"card border border-light p-3\">\n                    <ul class=\"list-unstyled mb-0\">\n                                              <li\n                          class=\"\"\n                        >\n                          <div class=\"label mb-1\">\n                            \n                          <\/div>\n                          <div class=\"value fw-bold\">Contact<\/div>\n                        <\/li>\n                                          <\/ul>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div\n        id=\"\"\n        class=\"wp-block-person-card margin-bottom-normal\"\n    >\n        <div class=\"container-lg\">\n            <div class=\"row justify-content-around\">\n                <div class=\"col-8 col-sm-6 col-md-12\">\n                    <a href=\"https:\/\/www.fh-joanneum.at\/en\/university\/person\/miriam-ressler\"\n    class=\"person-card\">\n    <div class=\"border border-light h-100\">\n\n        <div class=\"image-wrapper\">\n            <picture>\n        <img decoding=\"async\"\n        class=\"img-fluid\"\n        src=\"https:\/\/online.fh-joanneum.at\/JOANNEUMonline\/visitenkarte.showImage?pPersonenGruppe=3&amp;pPersonenId=4EE86FD91C8CBFAA\"\n        alt=\"\"\n        title=\"\"\n                 onerror=\"this.src = 'https:\/\/www.fh-joanneum.at\/app\/themes\/fh\/public\/images\/avatar_dummy.e5edf9.png'\"     >\n<\/picture>\n\n        <\/div>\n        <div class=\"p-2 p-xl-3\">\n                            <p class=\"mb-1 hyphens\">Mag.a Dr.<\/p>\n                        <h6>Miriam Re\u00dfler<\/h6>\n                        <p class=\"mb-0 hyphens\">\n              Senior Lecturer (FH)\n            <\/p>\n        <\/div>\n    <\/div>\n<\/a>                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n\n<div\n        id=\"\"\n        class=\"wp-block-person-card margin-bottom-normal\"\n    >\n        <div class=\"container-lg\">\n            <div class=\"row justify-content-around\">\n                <div class=\"col-8 col-sm-6 col-md-12\">\n                    <a href=\"https:\/\/www.fh-joanneum.at\/en\/university\/person\/bernhard-wagner\"\n    class=\"person-card\">\n    <div class=\"border border-light h-100\">\n\n        <div class=\"image-wrapper\">\n            <picture>\n        <img decoding=\"async\"\n        class=\"img-fluid\"\n        src=\"https:\/\/online.fh-joanneum.at\/JOANNEUMonline\/visitenkarte.showImage?pPersonenGruppe=3&amp;pPersonenId=25DE936C96D4CFAB\"\n        alt=\"\"\n        title=\"\"\n                 onerror=\"this.src = 'https:\/\/www.fh-joanneum.at\/app\/themes\/fh\/public\/images\/avatar_dummy.e5edf9.png'\"     >\n<\/picture>\n\n        <\/div>\n        <div class=\"p-2 p-xl-3\">\n                            <p class=\"mb-1 hyphens\">Mag. Dr.<\/p>\n                        <h6>Bernhard Wagner<\/h6>\n                        <p class=\"mb-0 hyphens\">\n              Senior Lecturer (FH)\n            <\/p>\n        <\/div>\n    <\/div>\n<\/a>                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n\n<div\n    id=\"\"\n    class=\"wp-block-text-card card margin-bottom-normal\"\n>\n    <div class=\"container-lg\">\n        <div class=\"row justify-content-around\">\n            <div class=\"col-8 col-sm-6 col-md-12\">\n                <div class=\"border border-light p-3\">\n                    <div class=\"module-migration-sidebar-ueberschrift-text\">\n<h4 class=\"field-migration-ueberschrift\">Research partners<\/h4>\n<p class=\"field-migration-text\">\n<ul>\n<li>Medical University of Graz<\/li>\n<li>University of Graz<\/li>\n<li>Helmholtz Zentrum M\u00fcnchen<\/li>\n<li>Universit\u00e8 de Lausanne<\/li>\n<li>Companies from the pharmaceutical, cosmetic and food industries<\/li>\n<\/ul>\n<\/div>\n\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div\n    id=\"\"\n    class=\"wp-block-text-card card margin-bottom-normal\"\n>\n    <div class=\"container-lg\">\n        <div class=\"row justify-content-around\">\n            <div class=\"col-8 col-sm-6 col-md-12\">\n                <div class=\"border border-light p-3\">\n                    <div class=\"module-migration-sidebar-ueberschrift-text\">\n<h4 class=\"field-migration-ueberschrift\">Funding provider<\/h4>\n<p class=\"field-migration-text\">\n<p>FFG, COIN (Cooperation &amp; Innovation) programme<\/p>\n<\/p>\n<\/div>\n\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n<\/div>\n\n<div class=\"d-none d-md-flex col-md-1 seperator-column\"><\/div>\n<div class=\"col-12 col-md-8 order-0 order-md-1\">\n     \n<div\n    id=\"\"\n    class=\"wp-block-intro-text margin-bottom-normal\"\n>\n    <div class=\"container-lg\">\n        <div class=\"row\">\n            <div class=\"col\">\n                <div class=\"major-text-color fst-italic\"><div class=\"module-migration-intro-text\">\n<p class=\"field-migration-intro_textfield\">\n<p>The ChromSpecLab develops analytical methods for in-process optimisation in product development. The analytical focus lies on the quantification of analytes and on identifying and quantifying impurities in pharmaceutical products, cosmetics and food. The aim is to identify influencing factors during the formulation and production process and to characterise the packaging materials used. <\/p>\n<p>Scientifically grounded findings are translated into application-oriented processes in close cooperation with partners from industry in order to increase the safety of patients and consumers on a continuous basis.  <\/p>\n<\/p>\n<\/div>\n<\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"\" class=\"wp-block-text-content margin-bottom-normal\">\n    <div class=\"container-lg\">\n        <div class=\"row\">\n            <div class=\"col\">\n                <p>The ChromSpec Lab can rely on <a href=\"#Infrastructure\">state-of-the-art infrastructure<\/a> for carrying out research assignments and collaborations with industry and academia as part of projects and degree theses. <\/p>\n<p>The key research areas include the optimisation and development of analytical methods with detection limits in the low ppb range in complex matrices and the processing and statistical analysis of measurement data. Chromatographic separation techniques are applied to quantify volatile, semi-volatile and non-volatile compounds in complex samples. The focus is on the identification, characterisation and quantification of by-products in the production of pharmaceuticals and of migrating packaging components and the characterisation of polymers.<\/p>\n<p>The laboratory is equipped to handle analytical tasks in the following research areas:<\/p>\n<ul>\n<li><a href=\"#Process\"><strong>In-process purity testing and identification of impurities<\/strong><\/a><\/li>\n<li><a href=\"#Migration\"><strong>Migrating packaging components: extractables and leachables<\/strong><\/a><\/li>\n<li><strong>Method development for biomarker identification<\/strong>&emsp;<\/li>\n<\/ul>\n<p><a name=\"Process\"><\/a><\/p>\n\n            <\/div>\n        <\/div>\n            <\/div>\n<\/div>\n\n<div id=\"\" class=\"wp-block-text-content margin-bottom-none\">\n    <div class=\"container-lg\">\n        <div class=\"row\">\n            <div class=\"col\">\n                <div class=\"module-migration-headline\">\n<h4>In-process purity testing and identification of impurities <\/h4>\n<\/div>\n\n            <\/div>\n        <\/div>\n            <\/div>\n<\/div>\n\n<div\n    id=\"\"\n    class=\"wp-block-image-slider margin-bottom-normal\"\n>\n    <div class=\"container-lg\">\n        <div class=\"row\">\n            <div class=\"col-12\">\n                <div class=\"swiper-outer-wrapper\">\n                    <div class=\"image-header\">\n                        <div class=\"swiper-navigation\">\n                            <div class=\"swiper-button-prev-custom\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"9\" height=\"14\" viewBox=\"0 0 9 14\" fill=\"none\">\n  <path d=\"M8 13L2 7L8 1\" stroke=\"\" stroke-width=\"1.5\" stroke-linecap=\"round\"\/>\n<\/svg>                            <\/div>\n                            <div class=\"swiper-button-next-custom\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"9\" height=\"14\" viewBox=\"0 0 9 14\" fill=\"none\">\n  <path d=\"M1 1L7 7L1 13\" stroke=\"\" stroke-width=\"1.5\" stroke-linecap=\"round\"\/>\n<\/svg>                            <\/div>\n                        <\/div>\n                    <\/div>\n                    <div class=\"swiper image-slider-swiper\">\n                        <div class=\"swiper-wrapper\">\n                                                                                                <div class=\"swiper-slide item\">\n                                        <picture>\n                        <source\n                media=\"(max-width: 576px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-7.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-7-768x386.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 768px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-7-768x386.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-7-1024x515.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 1024px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-7-1024x515.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-7.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 1170px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-7.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-7.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 1170px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-7.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-7.jpg 2x\"\n            \/>\n                <img decoding=\"async\"\n        class=\"img-fluid\"\n        src=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-7.jpg\"\n        alt=\"FH JOANNEUM - Labor f\u00fcr Metabolomik\"\n        title=\"\"\n         loading=\"lazy\"             >\n<\/picture>\n\n                                                                            <\/div>\n                                                                    <div class=\"swiper-slide item\">\n                                        <picture>\n                        <source\n                media=\"(max-width: 576px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-3.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-3-768x512.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 768px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-3-768x512.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-3-1024x683.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 1024px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-3-1024x683.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-3.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 1536px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-3.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-3.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 2048px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-3.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-3.jpg 2x\"\n            \/>\n                <img decoding=\"async\"\n        class=\"img-fluid\"\n        src=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-3.jpg\"\n        alt=\"Labor f\u00fcr chromatographische &amp;amp; spektrometrische Analytik 2\"\n        title=\"\"\n         loading=\"lazy\"             >\n<\/picture>\n\n                                                                            <\/div>\n                                                                    <div class=\"swiper-slide item\">\n                                        <picture>\n                        <source\n                media=\"(max-width: 576px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-2.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-2-768x513.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 768px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-2-768x513.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-2-1024x684.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 1024px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-2-1024x684.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-2.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 1536px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-2.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-2.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 2048px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-2.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-2.jpg 2x\"\n            \/>\n                <img decoding=\"async\"\n        class=\"img-fluid\"\n        src=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-2.jpg\"\n        alt=\"Labor f\u00fcr chromatographische &amp;amp; spektrometrische Analytik 1\"\n        title=\"\"\n         loading=\"lazy\"             >\n<\/picture>\n\n                                                                            <\/div>\n                                                                                    <\/div>\n                    <\/div>\n\n                    <div class=\"swiper-navigation-pagination\">\n                        <div class=\"swiper-button-prev-custom\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"9\" height=\"14\" viewBox=\"0 0 9 14\" fill=\"none\">\n  <path d=\"M8 13L2 7L8 1\" stroke=\"\" stroke-width=\"1.5\" stroke-linecap=\"round\"\/>\n<\/svg>                        <\/div>\n                        <div class=\"swiper-pagination\"><\/div>\n                        <div class=\"swiper-button-next-custom\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"9\" height=\"14\" viewBox=\"0 0 9 14\" fill=\"none\">\n  <path d=\"M1 1L7 7L1 13\" stroke=\"\" stroke-width=\"1.5\" stroke-linecap=\"round\"\/>\n<\/svg>                        <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"\" class=\"wp-block-text-content margin-bottom-normal\">\n    <div class=\"container-lg\">\n        <div class=\"row\">\n            <div class=\"col\">\n                <p>Impurities are components of active agents or pharmaceuticals which are chemically different from the active ingredient, the excipient or other additives. Potential sources of impurities include raw materials, solvents, intermediates, excipients and their decomposition products, which may form during production and storage. <\/p>\n<p>Impurity testing, identification and quantification represent important development steps in ensuring the purity, safety and quality of pharmaceutical or food products. Specific highly sensitive methods are required to detect, isolate and qualify these impurities, which are often present in very small amounts and in complex sample matrices. <\/p>\n<p>Better insight into the active ingredient and the pharmaceutical product as also their development at laboratory scale through to upscaling processes enables even complex production processes to be addressed in an ever stricter regulatory environment. These questions can be addressed by studies with a high level of analytical expertise and robust analytical results.<\/p>\n<p>The scientists at the ChromSpec Lab adapt and develop analytical methods to identify and quantify these unknown substances. They use stability studies to simulate degradation processes and to identify and quantify potentially harmful compounds.<\/p>\n<p>Structural characterisation is carried out using different ionisation techniques (EI, CI, ESI, APCI) for GC and LC mass spectrometry and a two-dimensional chromatography system in comprehensive and multiple heart-cutting mode.<\/p>\n<p><a name=\"Migration\"><\/a><\/p>\n\n            <\/div>\n        <\/div>\n            <\/div>\n<\/div>\n\n<div id=\"\" class=\"wp-block-text-content margin-bottom-none\">\n    <div class=\"container-lg\">\n        <div class=\"row\">\n            <div class=\"col\">\n                <div class=\"module-migration-headline\">\n<h4>Migrating packaging components: extractables and leachables<\/h4>\n<\/div>\n\n            <\/div>\n        <\/div>\n            <\/div>\n<\/div>\n\n<div\n    id=\"\"\n    class=\"wp-block-image-slider margin-bottom-normal\"\n>\n    <div class=\"container-lg\">\n        <div class=\"row\">\n            <div class=\"col-12\">\n                <div class=\"swiper-outer-wrapper\">\n                    <div class=\"image-header\">\n                        <div class=\"swiper-navigation\">\n                            <div class=\"swiper-button-prev-custom\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"9\" height=\"14\" viewBox=\"0 0 9 14\" fill=\"none\">\n  <path d=\"M8 13L2 7L8 1\" stroke=\"\" stroke-width=\"1.5\" stroke-linecap=\"round\"\/>\n<\/svg>                            <\/div>\n                            <div class=\"swiper-button-next-custom\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"9\" height=\"14\" viewBox=\"0 0 9 14\" fill=\"none\">\n  <path d=\"M1 1L7 7L1 13\" stroke=\"\" stroke-width=\"1.5\" stroke-linecap=\"round\"\/>\n<\/svg>                            <\/div>\n                        <\/div>\n                    <\/div>\n                    <div class=\"swiper image-slider-swiper\">\n                        <div class=\"swiper-wrapper\">\n                                                                                                <div class=\"swiper-slide item\">\n                                        <picture>\n                        <source\n                media=\"(max-width: 576px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-6.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-6-768x513.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 768px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-6-768x513.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-6-1024x684.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 1024px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-6-1024x684.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-6.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 1536px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-6.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-6.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 2048px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-6.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-6.jpg 2x\"\n            \/>\n                <img decoding=\"async\"\n        class=\"img-fluid\"\n        src=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-chromatographische-spektrometrische-analytik-6.jpg\"\n        alt=\"Labor f\u00fcr chromatographische &amp;amp; spektrometrische Analytik 5\"\n        title=\"\"\n         loading=\"lazy\"             >\n<\/picture>\n\n                                                                            <\/div>\n                                                                    <div class=\"swiper-slide item\">\n                                        <picture>\n                        <source\n                media=\"(max-width: 576px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-6.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-6-768x386.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 768px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-6-768x386.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-6-1024x515.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 1024px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-6-1024x515.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-6.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 1170px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-6.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-6.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 1170px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-6.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-6.jpg 2x\"\n            \/>\n                <img decoding=\"async\"\n        class=\"img-fluid\"\n        src=\"https:\/\/cdn3.fh-joanneum.at\/media\/2016\/05\/labor-fuer-metabolomik-6.jpg\"\n        alt=\"FH JOANNEUM - Labor f\u00fcr Metabolomik\"\n        title=\"\"\n         loading=\"lazy\"             >\n<\/picture>\n\n                                                                            <\/div>\n                                                                                    <\/div>\n                    <\/div>\n\n                    <div class=\"swiper-navigation-pagination\">\n                        <div class=\"swiper-button-prev-custom\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"9\" height=\"14\" viewBox=\"0 0 9 14\" fill=\"none\">\n  <path d=\"M8 13L2 7L8 1\" stroke=\"\" stroke-width=\"1.5\" stroke-linecap=\"round\"\/>\n<\/svg>                        <\/div>\n                        <div class=\"swiper-pagination\"><\/div>\n                        <div class=\"swiper-button-next-custom\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"9\" height=\"14\" viewBox=\"0 0 9 14\" fill=\"none\">\n  <path d=\"M1 1L7 7L1 13\" stroke=\"\" stroke-width=\"1.5\" stroke-linecap=\"round\"\/>\n<\/svg>                        <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"\" class=\"wp-block-text-content margin-bottom-normal\">\n    <div class=\"container-lg\">\n        <div class=\"row\">\n            <div class=\"col\">\n                <p>Components of primary packaging materials and medicinal products can migrate into the packaged product or metabolically interact with product components. Assessing and mitigating the risk of extractables and leachables from packaging materials for foods and medicines poses a substantial challenge to supervisory authorities and manufacturers. A comprehensive analysis includes the identification and quantification of these components, taking into account the adverse biological effects of the individual chemical structures. Compounds such as softeners or other polymer additives used in the manufacture of polymer-based packaging material are endocrine disruptors suspected of influencing the human immune system and thus the regulatory processes in the body.<\/p>\n<p>A multi-dimensional screening model was developed to investigate the migration and bioactive potential of these sensitive and unstable substances. When combined with selective and quantitative detection techniques, this model allows volatile, semi-volatile and non-volatile compounds to be detected and provides information about the chemical and immunomodulatory properties of the substances detected <em>in vitro<\/em>.<\/p>\n<p><a name=\"Infrastructure\"><\/a><\/p>\n\n            <\/div>\n        <\/div>\n            <\/div>\n<\/div>\n\n<div id=\"\" class=\"wp-block-text-content margin-bottom-none\">\n    <div class=\"container-lg\">\n        <div class=\"row\">\n            <div class=\"col\">\n                <div class=\"module-migration-headline\">\n<h4>Infrastructure<\/h4>\n<\/div>\n\n            <\/div>\n        <\/div>\n            <\/div>\n<\/div>\n\n<div id=\"\" class=\"wp-block-text-content margin-bottom-normal\">\n    <div class=\"container-lg\">\n        <div class=\"row\">\n            <div class=\"col\">\n                <p>The ChromSpecLab offers support in optimising holistic analytical processes using GC-MS\/MS and LC-MS\/MS methods, from experimental design (e.g. study design, sample preparation, extraction), choice of the analytical setup and adaptation of device-specific parameters through to data processing and statistical analysis.  <\/p>\n<p>The team of experienced specialists can draw on an extensive infrastructure including a range of GC\/MS and LC\/MS systems:<\/p>\n<h6>Gas chromatography &ndash; mass spectrometry:<\/h6>\n<ul>\n<li>Agilent 7890B GC with Agilent 7010C Triple Quadrupole MS with EI\/NCI ionisation<\/li>\n<li>PAL 3 RSI Autosampler with headspace, SPME and injection module<\/li>\n<li>Agilent 7890B GC with Agilent 5977B Single Quadrupole MS with EI\/NCI ionisation <\/li>\n<li>Agilent 6890 GC with Agilent 5975 Single Quadrupole MS and 7697A Headspace Sampler<\/li>\n<li>Agilent 6890 GC-FID with 7697A Headspace Sampler<\/li>\n<\/ul>\n<h6>Liquid chromatography &ndash; mass spectrometry<\/h6>\n<ul>\n<li>Agilent 6460 Triple Quadrupole MS with ESI\/APCI ionisation<\/li>\n<li>Agilent 1290 Infinity II 2D-UHLC System<\/li>\n<li>Agilent 1290 Infinity UHPLC System<\/li>\n<li>Agilent 1290 Infinity II Evaporative Light Scattering Detector<\/li>\n<li>Agilent 1260 Infinity UHPLC System with Fraction Collector<\/li>\n<li>Thermo LCQ Fleet<\/li>\n<li>UHPLC Accela 1000<\/li>\n<\/ul>\n\n            <\/div>\n        <\/div>\n            <\/div>\n<\/div>\n\n\n<\/div>\n\n\n        <\/div>\n    <\/div>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>The ChromSpecLab develops analytical methods for in-process optimisation in product development. The analytical focus lies on the quantification of analytes and on identifying and quantifying impurities in pharmaceutical products, cosmetics and food. The aim is to identify influencing factors during the formulation and production process and to characterise the packaging materials used. <\/p>\n","protected":false},"author":11,"featured_media":10022298,"template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.fh-joanneum.at\/en\/wp-json\/wp\/v2\/laboratory\/10007730"}],"collection":[{"href":"https:\/\/www.fh-joanneum.at\/en\/wp-json\/wp\/v2\/laboratory"}],"about":[{"href":"https:\/\/www.fh-joanneum.at\/en\/wp-json\/wp\/v2\/types\/laboratory"}],"author":[{"embeddable":true,"href":"https:\/\/www.fh-joanneum.at\/en\/wp-json\/wp\/v2\/users\/11"}],"version-history":[{"count":0,"href":"https:\/\/www.fh-joanneum.at\/en\/wp-json\/wp\/v2\/laboratory\/10007730\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fh-joanneum.at\/en\/wp-json\/wp\/v2\/media\/10022298"}],"wp:attachment":[{"href":"https:\/\/www.fh-joanneum.at\/en\/wp-json\/wp\/v2\/media?parent=10007730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}