{"id":100196202,"date":"2024-07-09T08:59:51","date_gmt":"2024-07-09T06:59:51","guid":{"rendered":"https:\/\/www.fh-joanneum.at\/?post_type=project&#038;p=100196202"},"modified":"2024-07-09T08:59:56","modified_gmt":"2024-07-09T06:59:56","slug":"endothelial-dysfunction-in-post-infection-fatigue-syndromes","status":"publish","type":"project","link":"https:\/\/www.fh-joanneum.at\/en\/project\/endothelial-dysfunction-in-post-infection-fatigue-syndromes\/","title":{"rendered":"Endothelial dysfunction in post-infection fatigue syndromes"},"content":{"rendered":"<div class=\"wp-block-sidebar-layout-container margin-bottom-normal\">\n    <div\n        class=\"container-lg\"\n        style=\"--bs-gutter-x: 0;\"\n    >\n        <div\n            class=\"row\"\n            style=\"--bs-gutter-x: 0;\"\n        >\n            \n<div class=\"col-12 col-md-3 order-1 order-md-0 sidebar\">\n            \n<div\n    id=\"\"\n    class=\"wp-block-institute-card margin-bottom-normal\"\n>\n    <div class=\"container-lg\">\n                                    <div class=\"row justify-content-around\">\n                    <div class=\"col-8 col-sm-6 col-md-12\">\n                        <a\n        class=\"gesundheitsstudien institute-card\"\n        href=\"https:\/\/www.fh-joanneum.at\/en\/institute\/biomedical-science\/\"\n        target=\"_self\"\n    >\n                            <div class=\"major-bg-color\">\n            <div class=\"wrapper\">\n                <div class=\"header\">\n                    <span>Institute<\/span>\n                <\/div>\n                <h4>Biomedical Science<\/h4>\n            <\/div>\n        <\/div>\n            <span><\/span>\n                    <\/a>\n                    <\/div>\n                <\/div>\n                        <\/div>\n<\/div>\n\n\n<div\n    id=\"\"\n    class=\"wp-block-text-card card margin-bottom-normal\"\n>\n    <div class=\"container-lg\">\n        <div class=\"row justify-content-around\">\n            <div class=\"col-8 col-sm-6 col-md-12\">\n                <div class=\"border border-light p-3\">\n                    <h3>Contact:<\/h3>\n\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n<div\n        id=\"\"\n        class=\"wp-block-person-card margin-bottom-normal\"\n    >\n        <div class=\"container-lg\">\n            <div class=\"row justify-content-around\">\n                <div class=\"col-8 col-sm-6 col-md-12\">\n                    <a href=\"https:\/\/www.fh-joanneum.at\/en\/university\/person\/francisco-westermeier\"\n    class=\"person-card\">\n    <div class=\"border border-light h-100\">\n\n        <div class=\"image-wrapper\">\n            <picture>\n        <img decoding=\"async\"\n        class=\"img-fluid\"\n        src=\"https:\/\/online.fh-joanneum.at\/JOANNEUMonline\/visitenkarte.showImage?pPersonenGruppe=3&amp;pPersonenId=48011AB2C5547DDE\"\n        alt=\"\"\n        title=\"\"\n                 onerror=\"this.src = 'https:\/\/www.fh-joanneum.at\/app\/themes\/fh\/public\/images\/avatar_dummy.e5edf9.png'\"     >\n<\/picture>\n\n        <\/div>\n        <div class=\"p-2 p-xl-3\">\n                        <h6>Francisco Westermeier<\/h6>\n                            <p class=\"mb-1 hyphens\"> BSc MSc PhD<\/p>\n                        <p class=\"mb-0 hyphens\">\n              Senior Lecturer (FH)\n            <\/p>\n        <\/div>\n    <\/div>\n<\/a>                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n\n\n<div id=\"\" class=\"wp-block-fact-box margin-bottom-normal\">\n  <div class=\"container-lg\">\n        <div class=\"row justify-content-around\">\n            <div class=\"col-8 col-sm-6 col-md-12\">\n                <div class=\"card border border-light p-3\">\n                    <ul class=\"list-unstyled mb-0\">\n                                              <li\n                          class=\"\"\n                        >\n                          <div class=\"label mb-1\">\n                            Project duration \n                          <\/div>\n                          <div class=\"value fw-bold\">July 1st, 2024 \/ June 30th, 2027<\/div>\n                        <\/li>\n                                          <\/ul>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n<div\n    id=\"\"\n    class=\"wp-block-text-card card margin-bottom-normal\"\n>\n    <div class=\"container-lg\">\n        <div class=\"row justify-content-around\">\n            <div class=\"col-8 col-sm-6 col-md-12\">\n                <div class=\"border border-light p-3\">\n                    <h3>Partners:<\/h3>\n<ul>\n<li>Eva Untersmayr-Elsenhuber, MD, PhD (Medical University of Vienna)<\/li>\n<li>Carmen Scheibenbogen, MD, PhD (Charit\u00e9 &#8211; Universit\u00e4tsmedizin Berlin)<\/li>\n<li>Martina Seifer, PhD (Charit\u00e9 &#8211; Universit\u00e4tsmedizin Berlin)<\/li>\n<li>Nuno Sep\u00falveda (Warsaw University of Technology, Warsaw, Poland)<\/li>\n<\/ul>\n\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n<div id=\"\" class=\"wp-block-partner-card margin-bottom-normal\">\n  <div class=\"container-lg\">\n      <div class=\"row justify-content-around\">\n          <div class=\"col-8 col-sm-6 col-md-12\">\n              <a href=\"https:\/\/www.meduniwien.ac.at\/web\/\">\n                  <div class=\"border border-light\">\n                      <picture>\n                        <source\n                media=\"(max-width: 576px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/med-uni-wien-576x432.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/med-uni-wien-768x576.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 768px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/med-uni-wien-768x576.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/med-uni-wien.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 866px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/med-uni-wien.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/med-uni-wien.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 866px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/med-uni-wien.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/med-uni-wien.jpg 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 866px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/med-uni-wien.jpg, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/med-uni-wien.jpg 2x\"\n            \/>\n                <img decoding=\"async\"\n        class=\"img-fluid\"\n        src=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/med-uni-wien.jpg\"\n        alt=\"\"\n        title=\"\"\n         loading=\"lazy\"             >\n<\/picture>\n\n                      <div class=\"p-3\">\n                          <p>Partner<\/p>\n                          <h4>Medical University of Vienna<\/h4>\n                          <p> <\/p>\n                      <\/div>\n                  <\/div>\n              <\/a>\n          <\/div>\n      <\/div>\n  <\/div>\n<\/div>\n\n\n<div id=\"\" class=\"wp-block-partner-card margin-bottom-normal\">\n  <div class=\"container-lg\">\n      <div class=\"row justify-content-around\">\n          <div class=\"col-8 col-sm-6 col-md-12\">\n              <a href=\"https:\/\/www.charite.de\/\">\n                  <div class=\"border border-light\">\n                      <picture>\n                        <source\n                media=\"(max-width: 576px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/charite-576x341.png, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/charite-768x455.png 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 768px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/charite-768x455.png, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/charite-1024x607.png 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 1024px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/charite-1024x607.png, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/charite.png 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 1489px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/charite.png, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/charite.png 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 1489px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/charite.png, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/charite.png 2x\"\n            \/>\n                <img decoding=\"async\"\n        class=\"img-fluid\"\n        src=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/charite.png\"\n        alt=\"\"\n        title=\"\"\n         loading=\"lazy\"             >\n<\/picture>\n\n                      <div class=\"p-3\">\n                          <p>Partner<\/p>\n                          <h4>Charit\u00e9 &#8211; Universit\u00e4tsmedizin Berlin<\/h4>\n                          <p> <\/p>\n                      <\/div>\n                  <\/div>\n              <\/a>\n          <\/div>\n      <\/div>\n  <\/div>\n<\/div>\n\n\n<div id=\"\" class=\"wp-block-partner-card margin-bottom-normal\">\n  <div class=\"container-lg\">\n      <div class=\"row justify-content-around\">\n          <div class=\"col-8 col-sm-6 col-md-12\">\n              <a href=\"https:\/\/eng.pw.edu.pl\/\">\n                  <div class=\"border border-light\">\n                      <picture>\n                        <source\n                media=\"(max-width: 300px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/Warsaw-University-of-technology.png, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/Warsaw-University-of-technology.png 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 300px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/Warsaw-University-of-technology.png, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/Warsaw-University-of-technology.png 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 300px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/Warsaw-University-of-technology.png, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/Warsaw-University-of-technology.png 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 300px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/Warsaw-University-of-technology.png, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/Warsaw-University-of-technology.png 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 300px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/Warsaw-University-of-technology.png, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/Warsaw-University-of-technology.png 2x\"\n            \/>\n                <img decoding=\"async\"\n        class=\"img-fluid\"\n        src=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/Warsaw-University-of-technology.png\"\n        alt=\"\"\n        title=\"\"\n         loading=\"lazy\"             >\n<\/picture>\n\n                      <div class=\"p-3\">\n                          <p>Partner<\/p>\n                          <h4>Warsaw University of Technology, Warsaw, Poland<\/h4>\n                          <p> <\/p>\n                      <\/div>\n                  <\/div>\n              <\/a>\n          <\/div>\n      <\/div>\n  <\/div>\n<\/div>\n\n\n<div id=\"\" class=\"wp-block-partner-card margin-bottom-normal\">\n  <div class=\"container-lg\">\n      <div class=\"row justify-content-around\">\n          <div class=\"col-8 col-sm-6 col-md-12\">\n              <a href=\"https:\/\/www.fwf.ac.at\/forschungsradar\/10.55776\/KLP9628023\">\n                  <div class=\"border border-light\">\n                      <picture>\n                        <source\n                media=\"(max-width: 576px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/FWF-576x97.png, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/FWF.png 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 661px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/FWF.png, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/FWF.png 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 661px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/FWF.png, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/FWF.png 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 661px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/FWF.png, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/FWF.png 2x\"\n            \/>\n                    <source\n                media=\"(max-width: 661px)\"\n                srcset=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/FWF.png, https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/FWF.png 2x\"\n            \/>\n                <img decoding=\"async\"\n        class=\"img-fluid\"\n        src=\"https:\/\/cdn3.fh-joanneum.at\/media\/2024\/07\/FWF.png\"\n        alt=\"\"\n        title=\"\"\n         loading=\"lazy\"             >\n<\/picture>\n\n                      <div class=\"p-3\">\n                          <p>Funded by <\/p>\n                          <h4>\u00d6sterreichischer Wissenschaftsfonds<\/h4>\n                          <p> <\/p>\n                      <\/div>\n                  <\/div>\n              <\/a>\n          <\/div>\n      <\/div>\n  <\/div>\n<\/div>\n\n\n<\/div>\n\n\n<div class=\"d-none d-md-flex col-md-1 seperator-column\"><\/div>\n<div class=\"col-12 col-md-8 order-0 order-md-1\">\n    \n<div\n    id=\"\"\n    class=\"wp-block-intro-text margin-bottom-normal\"\n>\n    <div class=\"container-lg\">\n        <div class=\"row\">\n            <div class=\"col\">\n                <div class=\"major-text-color fst-italic\"><p>The mechanisms of the development of endothelial dysfunction, which has been described as one of the key factors for the symptoms of ME\/CFS and Long Covid patients, are currently still largely unexplored. The project therefore aims to investigate key biological aspects related to endothelial cell function using plasma samples from an Austrian cohort of ME\/CFS and Long Covid patients.<\/p>\n<\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n<div id=\"\" class=\"wp-block-text-content margin-bottom-normal\">\n    <div class=\"container-lg\">\n        <div class=\"row\">\n            <div class=\"col\">\n                <p>Post-infection chronic fatigue syndromes, such as myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) and post-COVID-19 condition (Long Covid), are conditions primarily characterized by debilitating fatigue. This fatigue can range from mild, where patients are still able to participate in some social activities (e.g., school, work), to moderate and severe, where sufferers are predominantly homebound and bedridden.<\/p>\n<p>As a result, ME\/CFS and Long Covid not only negatively impact the quality of life of affected individuals and their caregivers but also represent a substantial and often silent burden on healthcare systems worldwide, including Austria. This is primarily because most cases remain undiagnosed due to the lack of standardized clinical assessments and diagnostic markers.<\/p>\n<p>Endothelial dysfunction, which is well known to affect blood flow, oxygen and nutrient delivery, and waste removal in the body, has been described as one of the key factors behind the symptoms experienced by ME\/CFS and Long Covid patients. However, the mechanisms that might explain the development of endothelial dysfunction remain largely unexplored.<\/p>\n<p>Therefore, this project aims to evaluate key biological aspects related to the function of endothelial cells &ndash; a layer of cells lining blood vessels &ndash; using plasma samples from an Austrian cohort of ME\/CFS and Long Covid patients. We expect that the findings from our study will provide new insights to better understand endothelial dysfunction in post-infection chronic fatigue syndromes, leading to improved patient stratification and tailored treatment alternatives.<\/p>\n<p><b>References<\/b><strong>:<\/strong><\/p>\n<p>1. Pipper C, Bliem L, Le&oacute;n LE, Mennickent D, Bodner C, Guzm&aacute;n-Guti&eacute;rrez E, Stingl M, Untersmayr E, Wagner B, Bertinat R, Sep&uacute;lveda N, Westermeier F (*). Sex and disease severity-based analysis of steroid hormones in ME\/CFS. Journal of Endocrinological Investigation. 2024. <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s40618-024-02334-1\" target=\"_blank\" rel=\"noopener noreferrer\">doi: 10.1007\/s40618-024-02334-1<\/a>.<\/p>\n<p>2. Bertinat R, Villalobos-Labra R, Hofmann L, Blauensteiner J, Sep&uacute;lveda N, Westermeier F (*). Decreased NO production in endothelial cells exposed to plasma from ME\/CFS patients. Vascular Pharmacology. 2022. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1537189122000027?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\">doi: 10.1016\/j.vph.2022.106953<\/a>.<\/p>\n<p>3. Blauensteiner J, Bertinat R, Le&oacute;n LE, Riederer M, Sep&uacute;lveda N, Westermeier F (*). Altered endothelial dysfunction-related miRs in plasma from ME\/CFS patients. Scientific Reports. 2021. <a href=\"https:\/\/www.nature.com\/articles\/s41598-021-89834-9\" target=\"_blank\" rel=\"noopener noreferrer\">doi: 10.1038\/s41598-021-89834-9.<\/a><\/p>\n\n            <\/div>\n        <\/div>\n            <\/div>\n<\/div>\n\n\n<\/div>\n\n\n        <\/div>\n    <\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":143,"featured_media":100196198,"template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.fh-joanneum.at\/en\/wp-json\/wp\/v2\/project\/100196202"}],"collection":[{"href":"https:\/\/www.fh-joanneum.at\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.fh-joanneum.at\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.fh-joanneum.at\/en\/wp-json\/wp\/v2\/users\/143"}],"version-history":[{"count":1,"href":"https:\/\/www.fh-joanneum.at\/en\/wp-json\/wp\/v2\/project\/100196202\/revisions"}],"predecessor-version":[{"id":100196204,"href":"https:\/\/www.fh-joanneum.at\/en\/wp-json\/wp\/v2\/project\/100196202\/revisions\/100196204"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fh-joanneum.at\/en\/wp-json\/wp\/v2\/media\/100196198"}],"wp:attachment":[{"href":"https:\/\/www.fh-joanneum.at\/en\/wp-json\/wp\/v2\/media?parent=100196202"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}