Gudrun Schappacher-Tilp



Gudrun Schappacher-Tilp completed her master’s degree in mathematics at the University of Graz (Austria) in 1999 and began working for Roche Diagnostics GmbH as a project manager. In parallel, she completed her doctoral research in mathematics in 2003 at the Institute for Mathematics and Scientific Computing, University of Graz. She returned to academia for a postdoctoral fellowship at the University of Calgary (Canada) from 2007 - 2008. After maternity leave, she won a postdoctoral research grant for highly qualified women (Hertha-Firnberg grant by the FWF). Her research was focused on mathematical models of muscle contraction. She subsequently held a senior postdoc position at the University of Graz, during which she also completed a doctoral program in medical sciences at the Medical University Graz. In 2020, she started as a senior lecturer at the electronics and computer engineering department at the FH Joanneum – University of Applied Sciences. Her main research interests are mathematical models of complex processes and their analysis and applications.
Her main motivation for teaching: love for applied mathematics and the belief that mathematical thinking is indispensable for problem-solving in applied sciences and engineering.

Selected peer-reviewed publications:
Herzog W, Schappacher-Tilp G. Molecular mechanisms of muscle contraction: A historical perspective. J Biomech. 2023 May 25;155:111659. doi: 10.1016/j.jbiomech.2023.111659. Epub ahead of print. PMID: 37290181.

Tiessen, Chris, et al. "Immunoglobulin domain unfolding and refolding in passively stretched myofibrils." Biophysical Journal 122.3 (2023): 115a.

Schappacher-Tilp G, Kotanko P, Pirklbauer M. Mathematical Models of Parathyroid Gland Biology: Complexity and Clinical Use. Frontiers in Nephrology 2022: 2.
doi: 10.3389/fneph.2022.893391

Leonard, T., Faridi, W., Ramrattan, D., Schappacher-Tilp, G., Moo, E. K., & Herzog, W. (2022). Skeletal muscle titin IG domain refolding after passive lengthening. Biophysical Journal, 121(3), 292a.

Tilp, Markus; Kitzberger, Lukas; Schappacher-Tilp, Gudrun; Birnbaumer, Philipp; Hofmann, Peter. Electromyographic and Systemic Physiological Thresholds in Single-Joint Elbow Flexion Movements. International Journal of Sports Physiology and Performance 2021. 1-8. doi:10.1123/ijspp.2021-0163

Pirklbauer M, Bushinsky DA, Kotanko P, Schappacher-Tilp G. Personalized Prediction of Short- and Long-Term PTH Changes in Maintenance Hemodialysis Patients. Front Med (Lausanne). 2021 Sep 14;8:704970. doi: 10.3389/fmed.2021.704970. eCollection 2021.PMID: 34595186

Shebl, Omar; Reiter, Elisabeth; Engel, Sabine; Allerstorfer, Christina; Schappacher-Tilp, Gudrun; Trautner, Philip; Rechberger, Tamara; Oppelt, Peter; Ebner, Thomas. Double ionophore application may improve rates of blastocyst formation and clinical pregnancy in cases of failed single application. Reproductive BioMedicine Online (2021), doi: https://doi.org/10.1016/j.rbmo.2021.11.008

Cherif, Alhaji; Maheshwari, Vaibhav ; Fuertinger, Doris; Schappacher-Tilp, Gudrun ; Preciado, Priscilla; Bushinsky, David; Thijssen, Stephan ; Kotanko, Peter. A mathematical model of the four cardinal acid-base disorders. Mathematical Biosciences and Engineering. 7,5. 2020. 4457-4476.

Schappacher-Tilp, Gudrun; Fuertinger D; Kotanko P. A Multi-Compartment Model Capturing the Pharmacokinetics of the Calcimimetic Cinacalcet. Cellular Physiology and Biochemistry. 53,2. 2019. 429-438. doi:10.33594/000000148

Schappacher-Tilp, Gudrun; Cherif, A; Fuertinger, Doris; Bushinsky, David; Kotanko, Peter. A mathematical model of parathyroid gland biology. Physiological Reports. 7,7. 2019. e14045. Under the top 10% of most downloaded papers 2020.

Schappacher-Tilp, Gudrun; Hymes, Jefferey; Fuertinger Doris; Stennett Amanda; Kotanko Peter. Thrice Weekly vs. Daily Cinacalcet: Virtual Clinical Trial and Its Subsequent Clinical Validation in a Large US Hemodialysis Population. ASN Kidney Week 2019 Washington, USA. Abstract: FR-PO130

Schappacher-Tilp, Gudrun; Cherif, A; Fuertinger, DH; Bushinsky, D; Kotanko, P. CKD Progression and bone metabolism: novel insights from a multi-scale physiology-based model. Nephrology Dialysis Transplantation. Oxford. Oxford Univ Press. 2019. FP470

Schappacher-Tilp, Gudrun. Titin-mediated thick filament activation stabilizes myofibrils on the descending limb of their force-length relationship. Journal of Sport and Health Science. 7,3. 2018. 326-332

Cherif, Alhaji; Maheshwari, Vaibhav; Preciado, Priscila; Fuertinger, Doris; Schappacher-Tilp, Gudrun; Thijssen, Stephan; Bushinsky, David; Kotanko, Peter. Predicting the safety and efficacy of buffer therapy to control acidemia in uremic patients. Nephrology Dialysis Transplantation. Oxford. Oxford Univ Press. 2019

Cherif, Alhaji; Preciado, Priscila; Maheshwari, Vaibhav; Fuertinger, Doris; Schappacher-Tilp, Gudrun; Thijssen, Stephan; Bushinsky, David; Kotanko, Peter. A mathematical model of bone remodeling in patients with uremia and metabolic bone diseases: Nephrology Dialysis Transplantation. Oxford. Oxford Univ Press 55th Congress of the European-Renal-Association (ERA) and European-Dialysis-and-Transplantation-Association (EDTA). Oxford. Oxford Univ Press. 2018.

Schappacher-Tilp, Gudrun; Fuertinger, Doris; Stennet, Amanda; Hymes, Jeffrey; Kotanko, Peter. Virtual cinical trial of cinacalcet in hemodialysis patients shows profound impact of patient adherence on parathyroid hormone levels. 55th Congress of the European-Renal-Association (ERA) and European-Dialysis-and-Transplantation-Association (EDTA). Nephrology Dialysis Transplantation. Oxford. Oxford Univ Press Oxford Univ Press. 2018. 168-168.

M. DuVall, Michael; Jinha, Azim; Schappacher-Tilp, Gudrun; Leonard, Timothy; Herzog, Walter. Differences in titin segmental elongation between passive and active stretch in skeletal muscle. In: The Journal of Experimental Biology 2017. 220(23):jeb.160762. DOI:10.1242/jeb.160762

Schappacher-Tilp, Gudrun; Herzog, Walter. Mechanosensing in myofilaments stabilizes the descending limb of force length relationship. ISB (Hg.): XXVI Congress of the International Society of Biomechanics. 2017. 495

Schappacher-Tilp, Gudrun; Preciado, Priscila; Maheshwari, Vaibhav; Cherif, Alhaji; Fuertinger, Doris, Thijssen, Stephan; Bushinsky, David; Kotanko, Peter. A Mathematical Model of Parathyroid Hormone Secretion in Uremic Patients. Kidney Week 2017. JASN (Journal of the American Society of Nephrology) 2017. FR-PO283

Maheshwari, Vaibhav; Cherif, Alhaji; Fuertinger, Doris; Schappacher-Tilp, Gudrun; Preciado, Priscila; Thijssen, Stephan; Bushinsky, David; Kotanko, Peter. An in-silico method to predict net calcium transfer during hemodialysis. IEEE Eng Med Biol Soc (Hg.): Conf Proc IEEE Eng Med Biol Soc. 2017.. IEEE. 2017.

Thomas; Tritscher, Katja; Mayer, Richard; Oppelt, Peter; Duba, Hans-Christoph; Maurer, Maria; Schappacher-Tilp, Gudrun; Petek, Erwin; Shebl, Omar. Quantitative and qualitative trophectoderm grading allows for prediction of live birth and gender. Journal of Assisted Reprodution and Genetics. 2016. 49-57.

Xue, Yuan; Schoser, Benedikt; Rao, Aliz R; Quadrelli, Roberto; Vaglio, Alicia; Rupp, Verena; Beichler, Christian; Nelson, Stanley; Schappacher-Tilp, Gudrun; Windpassinger, Christian; Wilcox, William. Exome Sequencing Identified a Splice Site Mutation inFHL1 that Causes Uruguay Syndrome, an X-Linked Disorder with Skeletal Muscle Hypertrophy and Premature Cardiac Death. Circulation: Cardiovascular Genetics. 9,2. 2016. 130-135.

Schappacher-Tilp, Gudrun; Leonard, Tim; Desch, Gertrud; Herzog, Walter. Computing average passive forces in sarcomeres in length-ramp simulations. PLoS Computational Biology (Online). 12,6. 2016. 1-14.

Herzog, Walter; Schappacher, Gudrun; DuVall, Michale; Leonard, Timothy; Herzog, Jens. Residual Force Enhancement Following Eccentric Contractions: A New Mechanism Involving Titin. Physiology. 31,4. 2016. 300-312

Ertl, Peter; Overgaard, Kristian; Sørensen, Henrik; Schappacher-Tilp, Gudrun; Kazimierski-Hentschel, Kamil; Tilp, Markus. The evaluation of automatically detected electromyographic thresholds. Baca A., Wessner B., Diketmüller R., Tschan H., Hofmann M., Kornfeind P.Tsolakidis E. (Hg.): Book of Abstracts. Cologne. Sportools

Schappacher-Tilp, Gudrun; Desch, Gertrud; Herzog, Walter. An efficient algorithm to estimate passive forces in sarcomeres under length control conditions. ISB 2015 Book of Abstracts. 2015. 792-793

Ebner, Thomas; Shebl, Omar; Tritscher, Katja; Oppelt, Peter; Duba, Hans-Christoph; M. Maurer; Schappacher-Tilp, Gudrun; Petek, Erwin; Mayer, Richard. Qualitative and quantitative grading of human blastocysts and its association with live-birth rate and neonatal outcome. Human Reproduction. 30. 2015. 44-45

Nerstheimer, Stefanie; Tauscher, Petra; Petek, Erwin; Schappacher-Tilp, Gudrun. HLA-frequencies of Austrian umbilical cord blood samples. Human Immunology. 76. 2015. 863-867.

Schappacher-Tilp, Gudrun; Leonard, Timothy; Desch, Gertrud; Herzog, Walter. A Novel Three-Filament Model of Force generation in eccentric Contraction of Skeletal Muscles. PLoS One. Doi: 10.1371/journal.pone.0117634. 2015. 1-16. Top 25% cited PloS One articles in 2017

Powers, Krysta; Schappacher-Tilp, Gudrun; Jinha, Azim; Leonard; Timothy; Nishikawa, Kiisa; Herzog, Walter. Titin Force is Enhanced in Actively Stretched Skeletal Muscle. The Journal of Experimental Biology. 217. 2014. 3629 - 3636.

Ebner, Thomas; Shebl, Omar; Holzer, Sandra; Oppelt, Peter; Petek, Erwin; Schappacher-Tilp, Gudrun; Mayer, Richard. Viability of cumulus cells is associated with basal AMH levels in assisted reproduction. European Journal of Obstetrics & Gynecology and Reproductive Biology. 183 (214). 2014. 59 - 63.

Schappacher-Tilp, Gudrun; Herzog, Walter. Prediction of force sharing among synergistic muscles. IFIP (Hg.): IFIP TC7 Conference System Modelling and Optimization Programme and Abstracts. 2013.

Schappacher-Tilp, Gudrun; Leonard, Tim; Desch, Gertrud; Herzog, Walter. A Structural Model of Force Generation in Single Myofibrils Aimed at Explaining Force Regulation in the Absence of Cross-Bridge Interaction. In: Gerhard Holzapfel and Ray W. Ogden (Hg.): ESMC 2012 8th European Solidy Mechanics Conference Graz, Austria. 2012.

M Seiringer, M; Maurer, Maria; Shebl, Omar; Freier, Kerstin; Tews, Gernot; Ziehr, Stephanie; Schappacher-Tilp, Gudrun; Petek, Erwin; Ebner, Thomas. Efficacy of a sperm-selection chamber in terms of morphology, aneuploidy and DNA packaging. Reproductive BioMedicine Online. 27,1. 2013. 81 – 88.

Schappacher-Tilp, Gudrun; Jinha, Azim; Herzog, Walter. Mapping the classical cross-bridge theory and backward steps in a three-bead laser trap setup. Mathematical Biosciences. 229 (2011),1. 2011. 115 - 122.

Changes in fascicle lengths and pennation angles give no explanation for residual force enhancement or depression during voluntary contractions in human tibialis anterior. Journal of Applied Biomechanics. 2011.

Porta, Sepp; Korisek, Gerd; Machan, Barbara; Gaggl, Herbert; Desch Wolfgang; Porta, Josef; Schappacher, Gudrun; Kisters, Klaus. Changes in electrolyte and metabolic interactions below the hypomagnesemic threshold in Type 2 diabetics. Trace Elements and Electrolytes. 27 (2010),3. 2010. 119 - 124.

Schappacher-Tilp, Gudrun; Herzog, Walter. A stochastic model of the three-bead laser trap setup to study actin-myosin interaction. ISB (Hg.): 6th World Congress of Biomechanics - Abstracts. 2010.

Schappacher-Tilp, Gudrun; Braverman, Elena; Binding, Paul; Herzog, Walter. Task dependent cost functions in a one degree of freedom model for the prediction of force sharing among synergistic muscles. ISB (Hg.): 6th World Congress of Biomechanics - Abstracts. 2010.

Schappacher-Tilp, Gudrun; Binding, Paul; Braverman, Elena; Herzog, Walter. Velocity-dependent cost function for the prediction of force sharing among synergistic muscles in a one degree of freedom model. Journal of Biomechanics. 42 (2009),5. 2009. 657 - 660.

Desch, Wolfgang.; Schappacher, Wilhelm; Schappacher, Gudrun; Wintersteiger, Reinhold; Ecker, M.; Köhler, U.; Korisek, G.; Porta, Sepp. An attempt to quantify the influence of some IC parameters upon the levels of ionized Mg in blood. In: Trace Elements and Electrolytes. 2/2009,26. 2009. 89 - 94.

Schappacher-Tilp, Gudrun; Herzog, Walter. Modelling the effect of Brownian motion on the amount of backwards steps in the classical three-beads laser trap setup for actin-myosin interaction. J.E. Ashton-Miller, R.E. Hughes, D.M. Andrews (Hg.): Proceedings of the North American Congress on Biomechanics. 2008.

Tilp, Markus; Steib, Simon; Schappacher-Tilp, Gudrun; Herzog, Walter. Residual Force Enhancement in Maximal Voluntary Contractions of Human Dorsi Flexors. J.E. Ashton-Miller, R.E. Hughes, D.M. Andrews (Hg.): Proceedings of the North American Congress on Biomechanics. 2008. Finalist Young Investigator Award

Desch, Wolfgang; Schappacher, Gudrun; Schappacher, Wilhelm. Relatively Bounded Rank One Perturbations of Nonanalytic Semigroups can generate Large Point Spectrum. Semigroup Forum. 75 (2007). 2007. 470 - 476.

Schappacher, Gudrun. A notion of Orlicz spaces for vector valued functions. Applications of Mathematics (New York, 1956). 50 (2005),4. 2005. 355 - 386.

Schappacher, Gudrun; Hartmann, Paul. Partial analytical solution of a model used for measuring oxygen diffusion coefficients of polymer films by luminescence quenching. Analytical Chemistry. 75 (2003),16. 2003. 4319 - 4324.

Schappacher-Tilp G; Kotanko P. Techniques for determining calcimimetic drug activity. U.S. Patent Application Nr. 17/491,900, 2023.

Schappacher-Tilp G; Kotanko P, Fuertinger, DH. Techniques for modeling parathyroid gland functionality and calcimimetic drug activity. U.S. Patent Nr. 11,450,405, 2022.

Lukas R, Schappacher G. US Patent No: 7,839,502: Method for the wavelength calibration of a spectrometer. Roche Diagnostics Graz GmbH